Caspase-3 Promotes Genetic Instability and Carcinogenesis
نویسندگان
چکیده
منابع مشابه
Essential roles of Caspase-3 in facilitating Myc-induced genetic instability and carcinogenesis
The mechanism for Myc-induced genetic instability is not well understood. Here we show that sublethal activation of Caspase-3 plays an essential, facilitative role in Myc-induced genomic instability and oncogenic transformation. Overexpression of Myc resulted in increased numbers of chromosome aberrations and γH2AX foci in non-transformed MCF10A human mammary epithelial cells. However, such inc...
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 2015
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2015.03.003